abstract：:Rhenium-186 (Re-186) hydroxyethylidene diphosphonate (HEDP) has been shown to localize in metastatic foci within bone in a manner similar to Tc-99m bone-seeking agents. Usually, in the preparation of diagnostic Tc-99m radiopharmaceuticals, the concentration of Tc is at trace level (10(-8) M). However, large amounts of...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Lin CP,Hsieh BT,Ting G,Wang SJ,Knapp FF Jr

更新日期：1999-05-01 00:00:00

abstract：:Ex vivo and in vitro autoradiography (ARG) with radioluminography is a useful technique to characterize newly developed 11C-labeled positron emission tomography (PET) tracers and to apply them to biological and pharmacological studies. In this report, we have described a method of evaluating the radioactivity distribu...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Ogi N,Tanaka A,Senda M

更新日期：1999-04-01 00:00:00

abstract：:A radiosynthetic method to prepare the nicotinic acetylcholine receptor radioligand (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine, 5-IA, has been developed. The two-step sequence produced [123I]-5-IA in high radiochemical yield (52%), high radiochemical purity (98%), and high specific radioactivities (> 8,500 mCi/m...

journal_title：Nuclear medicine and biology

authors： Musachio JL,Villemagne VL,Scheffel UA,Dannals RF,Dogan AS,Yokoi F,Wong DF

更新日期：1999-02-01 00:00:00

abstract：:We evaluated 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3)-biocytin as a hepatobiliary imaging agent in the absence and presence of bilirubin in mice. We then compared its pharmacokinetic parameters; peak liver/heart activity ratio (rmax) and half clearance time (HCT) with those of 99mTc-labeled diisopropyl-imin...

journal_title：Nuclear medicine and biology

authors： Kim M,Seidel J,Le N,Kim IS,Yoo TM,Barker C,Kobayashi H,Green MV,Carrasquillo JA,Paik CH

更新日期：1999-01-01 00:00:00

abstract：:We have synthesized N-(6-18F-fluorohexyl)-N-methylpropargylamine (18F-FHMP) as a positron emission tomography (PET) radiotracer for monoamine oxidase B (MAO-B). The radiosynthesis was carried out by a fluorine-for-bromine substitution in 30-40% radiochemical yield in specific activities of 1-2 Ci/micromol. Selectivity...

journal_title：Nuclear medicine and biology

authors： Mukherjee J,Yang ZY,Lew R

更新日期：1999-01-01 00:00:00

abstract：:Dual probe microdialysis was employed in intact rat brain to investigate the effect of intrastriatal perfusion with selective dopamine D1 and D2 receptor agonists and with c-fos antisense oligonucleotide on (a) local GABA release in the striatum; (b) the internal segment of the globus pallidus and the substantia nigra...

journal_title：Nuclear medicine and biology

authors： O'Connor WT

更新日期：1998-11-01 00:00:00

abstract：:The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAC...

journal_title：Nuclear medicine and biology

authors： Horti AG,Scheffel U,Koren AO,Ravert HT,Mathews WB,Musachio JL,Finley PA,London ED,Dannals RF

更新日期：1998-10-01 00:00:00

abstract：:ABSTRACT. The aim of the present study was to investigate the lymphatic cardiac circulation in an experimental model of ischemia plus reperfusion in mongrel dogs (Canis familiaris L). As radiotracer we used 0.2-0.25 ml (111 MBq) of 99mTc-Re2S7 colloid (+/-10 microm), injected subcapsullary below the second diagonal of...

journal_title：Nuclear medicine and biology

authors： Santos AC,de Lima JJ,Botelho MF,Pacheco MF,Sousa P,Bernardo J,Ferreira N,Gonçalves L,Aguiar J,Providência LA,Pauwels EK

更新日期：1998-10-01 00:00:00

abstract：:A consensus has emerged that early imaging (within 20 min post-injection [p.i.] of sestamibi) has the highest diagnostic yield. Tc-99m-sestamibi uptake has been associated with P-glycoprotein-mediated multi-drug resistance (MDR), tumor vascularization, invasiveness, and cell proliferation. The aim of this study was to...

journal_title：Nuclear medicine and biology

authors： Leitha T,Glaser C,Lang S

更新日期：1998-08-01 00:00:00

abstract：:111In-LDTPA galactose BSA (bovine serum albumin) was used to evaluate the asialoglycoprotein receptor (ASGPR) system in both normal and ASGPR-deficient mice. The radiolabeled glycoprotein had complete liver uptake in both normal and ASGPR-deficient mice. Metabolism and hepatic cell-type distribution studies were perfo...

journal_title：Nuclear medicine and biology

authors： Deal KA,Cristel ME,Welch MJ

更新日期：1998-05-01 00:00:00

abstract：:Synthesis and preliminary biological evaluation of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)-guanine ([18F]FHBG) is reported. 9-(4-Hydroxy-3-hydroxymethylbutyl)-guanine (penciclovir) 4 was converted to 9-[N2, O-bis-(methoxytrityl)-3-(tosylmethybutyl)]guanine 7 by treatment with methoxytrityl chloride followed by tosylat...

journal_title：Nuclear medicine and biology

authors： Alauddin MM,Conti PS

更新日期：1998-04-01 00:00:00

abstract：:The effect of acyclovir (ACV) on the metabolism of rat 9L-gliosarcoma cells expressing the herpes simplex virus-thymidine kinase gene was studied using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) and L-[methyl-11C]methionine. Though the average weight of the tumors treated with ACV was significantly lower than that of the s...

journal_title：Nuclear medicine and biology

authors： Namba H,Iwadate Y,Iyo M,Fukushi K,Irie T,Sueyoshi K,Tagawa M,Sakiyama S

更新日期：1998-04-01 00:00:00

abstract：:We report herein the preparation and biological evaluation of two radioastatinated biotin conjugates, (3-[211At]astatobenzoyl)norbiotinamide and ((5-[211At]astato-3-pyridinyl)carbonyl)norbiotinamide. Both conjugates were stable in the presence of human serum and cerebrospinal fluid as well as murine serum, indicating ...

journal_title：Nuclear medicine and biology

authors： Foulon CF,Alston KL,Zalutsky MR

更新日期：1998-02-01 00:00:00

abstract：:Liposomes encapsulating both glutathione and deferoxamine were labeled with 99mTc-HMPAO and 111In-oxine at the same time. These dual radiolabeled liposomes were intravenously injected in rats with S. aureus infection in thigh. The target-to-background ratio (T/BG) increased from 2.9 at 2 h to 4.4 at 8 h in 99mTc image...

journal_title：Nuclear medicine and biology

authors： Awasthi VD,Goins B,Klipper R,Phillips WT

更新日期：1998-02-01 00:00:00

abstract：:We have investigated whether [186Re]-labeled chimeric monoclonal antibody 323/A3 (MAb c-323/A3) is as effective as [186Re]-labeled mouse 323/A3 (m-323/A3) in the growth inhibition of human ovarian cancer xenografts OVCAR-3 and FMa. [186Re] was conjugated to MAbs with the use of the chelate S-benzoylmercaptoacetyltrigl...

journal_title：Nuclear medicine and biology

authors： Kievit E,van Gog FB,Schlüper HM,van Dongen GA,Pinedo HM,Boven E

更新日期：1998-01-01 00:00:00

abstract：:18Fluoro-norchloroepibatidine (exo-2-(6-fluoro-3-pyridyl)-7-azabicyclo-[2.2.1]heptane [NFEP]), a labeled derivative of epibatidine, has shown promise for imaging brain nicotinic acetylcholine receptors with PET. We determined the dose-dependent effects of NFEP in conscious rats. NFEP (1.5 microg/kg; administered intra...

journal_title：Nuclear medicine and biology

authors： Molina PE,Ding YS,Carroll FI,Liang F,Volkow ND,Pappas N,Kuhar M,Abumrad N,Gatley SJ,Fowler JS

更新日期：1997-11-01 00:00:00

abstract：:The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an elec...

journal_title：Nuclear medicine and biology

authors： Bergman J,Solin O

更新日期：1997-10-01 00:00:00

abstract：:A glucose analogue labelled with iodine-123 in position 6 has been synthesized: [123I]-6-deoxy-6-iodo-D-glucose (6DIG). The aim of this study was to examine its biological behaviour in order to assess whether it could be used to evaluate glucose transport with SPECT. To establish whether 6DIG enters the cells using th...

journal_title：Nuclear medicine and biology

authors： Henry C,Koumanov F,Ghezzi C,Morin C,Mathieu JP,Vidal M,de Leiris J,Comet M,Fagret D

更新日期：1997-08-01 00:00:00

abstract：:L-2,4-Diamino[4-11C]butyric acid (DAB) was synthesized by an enzyme catalysed carrier added (0.1 micromol KCN) reaction of hydrogen [11C]cyanide with O-acetyl-L-serine followed by reduction. L-[11C]DAB was obtained with a radiochemical purity higher than 96% and with a decay corrected radiochemical yield of 30-40% wit...

journal_title：Nuclear medicine and biology

authors： Antoni G,Omura H,Bergström M,Furuya Y,Moulder R,Roberto A,Sundin A,Watanabe Y,Långström B

更新日期：1997-08-01 00:00:00

abstract：:The syntheses and radiolabelling of 27 new N-(alkylaminoalkyl)-4-methoxy-, -4-hydroxy-, and -4-aminobenzamides are described and evaluated in C57B1/6 mice with subcutaneously transplanted B16 melanoma in order to screen the optimal chemical structure for melanoma scintigraphy. Using T1(TFA)3 for 131I- labelling, a ser...

journal_title：Nuclear medicine and biology

authors： Mohammed A,Nicholl C,Titsch U,Eisenhut M

更新日期：1997-07-01 00:00:00

abstract：:Dithiocarboxylate ligands were synthesized and characterised. New nitrido 99m-technetium complexes were obtained with these ligands and identified by thin layer chromatography. The nitrido complexes were tested in vitro in whole blood for leucocyte labelling and the design of the ligand was optimized. Best results wer...

journal_title：Nuclear medicine and biology

authors： Demaimay F,Noiret N,Roucoux A,Patin H,Bellande E,Pasqualini R,Moisan A

更新日期：1997-07-01 00:00:00

abstract：:The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in...

journal_title：Nuclear medicine and biology

authors： Kälkner KM,Ginman C,Nilsson S,Bergström M,Antoni G,Ahlström H,Långström B,Westlin JE

更新日期：1997-05-01 00:00:00

abstract：:A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation peri...

journal_title：Nuclear medicine and biology

authors： Zalutsky MR,Stabin MG,Larsen RH,Bigner DD

更新日期：1997-04-01 00:00:00

abstract：:The synthetic porphyrins, N-benzyl-5,10,15,20-tetrakis (4-carboxyphenyl) porphine (N-bzHTCPP) and N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine (N-bzHCS3P), represent excellent radiocopper chelating agents that may find utility in antibody-mediated diagnosis and/or therapy. N-bzHCS3P was co...

journal_title：Nuclear medicine and biology

authors： Bhalgat MK,Roberts JC,Mercer-Smith JA,Knotts BD,Vessella RL,Lavallee DK

更新日期：1997-02-01 00:00:00

abstract：:The present study was undertaken to investigate if pretreatment with pharmacological agents could change the organ uptake of 11C-labelled L-DOPA, and especially if the urinary excretion could be decreased. L-[beta-11C]DOPA was injected IV into unanesthetized Sprague-Dawley rats. After 20 min the rats were decapitated ...

journal_title：Nuclear medicine and biology

authors： Bergström M,Lu L,Marquez M,Fasth KJ,Bjurling P,Watanabe Y,Eriksson B,Långström B

更新日期：1997-01-01 00:00:00

abstract：:We report a single pass gas phase route to [11C]CH3I based on production of I from I2 at elevated temperature. I abstracts H from CH4 to yield CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessi...

journal_title：Nuclear medicine and biology

authors： Link JM,Krohn KA,Clark JC

更新日期：1997-01-01 00:00:00

abstract：:We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(v)(O)(GAM)2]-. After biodistribution and toxicity studies i...

journal_title：Nuclear medicine and biology

authors： Gianolli L,Dosio F,Matarrese M,Colombo F,Cutler C,Stepniak-Biniakiewicz D,Deutsch E,Savi A,Lucignani G,Fazio F

更新日期：1996-11-01 00:00:00

abstract：:To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the b...

journal_title：Nuclear medicine and biology

authors： Kuge Y,Kawashima H,Yamazaki S,Hashimoto N,Miyake Y

更新日期：1996-11-01 00:00:00

abstract：:The in vitro stability and animal pharmacokinetics of 99mTc bound to Sandoz and C110 IgG antibodies via a modified MAG3 has been compared with the hydrazino nicotinamide (SHNH) moiety as standard. For both antibodies, the stabilities of the label to challenge at up to 50:1 cysteine: IgG molar ratio were comparable, bu...

journal_title：Nuclear medicine and biology

authors： Lei K,Rusckowski M,Chang F,Qu T,Mardirossian G,Hnatowich DJ

更新日期：1996-10-01 00:00:00

abstract：:The aim of the study was to evaluate the diagnostic accuracy of scintimammography with Tc-99m MIBI for the detection of breast cancer. Patients with a suspicious lesion detected by palpation or mammography were included in the study. Excisional biopsy was performed on all patients. Mammography was performed within 3 w...

journal_title：Nuclear medicine and biology

authors： Palmedo H,Schomburg A,Grünwald F,Mallmann P,Boldt I,Biersack HJ

更新日期：1996-08-01 00:00:00

abstract：:Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake ...

journal_title：Nuclear medicine and biology

authors： McCarthy TJ,Dence CS,Holmberg SW,Markham J,Schuster DP,Welch MJ

更新日期：1996-08-01 00:00:00

abstract：:A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. Significantly higher (p < 0.05) uptake of [211At]MABG was seen in tumor (3.8 +/- 0.8% ID/g vs. 3.1 +/- 0.7% ID/g at...

journal_title：Nuclear medicine and biology

authors： Vaidyanathan G,Friedman HS,Keir ST,Zalutsky MR

更新日期：1996-08-01 00:00:00

abstract：:A comprehensive evaluation of the reactivity of 18F electrophilic fluorinating agents derived from the 18O(p,n)18F reaction conducted in target bodies made of aluminum, silver, copper, nickel, and gold-plated copper is reported. Two representative electrophilic reactions, namely addition across a double bond and subst...

journal_title：Nuclear medicine and biology

authors： Bishop A,Satyamurthy N,Bida G,Barrio JR

更新日期：1996-07-01 00:00:00

abstract：:A simple, rapid, and reproducible micromethod for quantification of sulfhydryl (SH) groups generated after reduction of monoclonal antibody (MAb) disulfide bonds with 2-mercaptoethanol (2-ME) is described. The number of SH groups per molecule of antibody in the 2-ME and in the other reducing agents was calculated from...

journal_title：Nuclear medicine and biology

authors： Iznaga Escobar N,Morales A,Núñez G

更新日期：1996-07-01 00:00:00

abstract：:Pretargeted tumour imaging was performed in nude mice bearing subcutaneous LS174T human colon cancer xenografts with streptavidin-CC49 monoclonal antibody and 111In-DTPA-biocytin. Mice were administered 250 micrograms of streptavidin-CC49, followed 6 or 9 days later by 40 ng (250 microCi) of 111In-DTPA-biocytin. Tumor...

journal_title：Nuclear medicine and biology

authors： Alvarez-Diez TM,Polihronis J,Reilly RM

更新日期：1996-05-01 00:00:00

abstract：:Applications of oligodeoxynucleotides to modulate gene expression have been the subject of much recent research. We have sought to develop a method to permanently inactivate a gene, or potentially kill cells containing abnormal genes. In this report, we show that a DNA intercalator conjugated to a triplex-forming olig...

journal_title：Nuclear medicine and biology

authors： Orson FM,McShan WM,Kinsey BM

更新日期：1996-05-01 00:00:00

abstract：:Brofaromine (4-5(-methoxy-7-bromobenzofuranyl)-2-piperidine-HCl) is a potent and selective inhibitor of monoamine oxidase (MAO) A. Two methods for its synthesis and a preliminary positron emission tomography (PET) evaluation in monkey brain are described. The first method, at low carrier concentration of CO2, consiste...

journal_title：Nuclear medicine and biology

authors： Ametamey SM,Beer HF,Guenther I,Antonini A,Leenders KL,Waldmeier PC,Schubiger PA

更新日期：1996-04-01 00:00:00

abstract：:In the quantitative studies of presynaptic dopamine metabolism by PET with 6-[18F]fluoro-L-dopa (6-[18F]FDOPA), metabolic analysis in the plasma is required to determine the precise input function because of susceptibility of the compound to peripheral metabolism. In this study, we prepared 6-[18F]-fluoro-O-pivaloyl-L...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Shinoda M,Ishii S,Nozaki T,Senda M

更新日期：1996-04-01 00:00:00

abstract：:By variation of reaction parameters iodination of 3-(9,10-didehydro-6-methyl-8 alpha-ergolinyl)-1,1-diethylurea (lisuride) was performed with the radiohalogen [123I]iodine (t1/2 = 13.3 h). For comparative experiments and stability studies the beta(-)-emitting radioisotope [131I]iodine (t1/2 = 8.04 d) was also used. Re...

journal_title：Nuclear medicine and biology

authors： Bier D,Dutschka K,Knust EJ

更新日期：1996-04-01 00:00:00

abstract：:In vivo pharmacokinetic and brain binding characteristics of [18F]RP 62203, a selective high-affinity serotonergic 5-HT2A receptor antagonist, were assessed in the rat following intravenous injection of trace amount of the radioligand. The radioactive distribution profile observed in the brain 60 min after injection w...

journal_title：Nuclear medicine and biology

authors： Besret L,Dauphin F,Huard C,Lasne MC,Vivet R,Mickala P,Barbelivien A,Baron JC

更新日期：1996-02-01 00:00:00